Earlier this year we took a look at the defensive behaviors of honeybees. Let's take a closer look now at the substance that makes their defense such an effective one.
What is bee venom made of?
Honeybee venom is an acidic, bitter substance that bees inject into their perceived attacker using their stinger. When a bee stings something, she injects about .1 mg of the colorless fluid through her stinger. This venom, when injected under the skin, can cause pain, swelling, and many other reactions.
The venom is also called apitoxin and is made up of many proteins and peptides that have many different properties, or effects. In fact, it is made of over 20 active substances. The main part of bee venom are several proteins, called melittin, that cause pain. Melittin is also one of the most potent anti-inflammatory agents known. It is up to 100 times stronger than hydrocortisol. The Schmidt Sting Pain Index rates the pain of stings from 78 species of ants, bees, and wasps on a scale of 1-4. A honeybee’s sting is scored at 2 on the scale and is “Like a matchhead that flips off and burns on your skin.”
Other parts of apitoxin include agents that act on the adrenal glands and stimulate cortisol production. There are also small amounts of neurotoxin and anti-inflammatory agents. However, besides melittin, the other major component of apitoxin is histamine. Histamine is what causes allergic reactions in animals. Allergies are overreactions of the immune system.
What is the effect of bee venom on humans?
Humans have different levels of sensitivity to the histamine in bee venom. Statistically, 0.5% to 5% of people have extreme allergic reactions to bee stings. These people are extremely sensitive, or hypersensitive, to the bee venom histamine. An adult with little sensitivity could take over a thousand stings. For a hypersensitive person, only one sting could result in serious to deadly effects.
Some people have been stung many times in their life with only the normal, mild effects and then are later stung and have a severe reaction. Hypersensitivity to bee venom can develop later for some people. Also, people who are on anti-inflammatory treatments can have a very serious reaction to stings. Beekeepers who have never had problems with stings have reported moderate to seriously increased sensitivity after consistently taking NSAIDS like ibuprofen and naproxen (Advil and Aleve).
A bee sting is generally only mildly painful with a little bit of swelling and itching. These symptoms only last for a few days at most. For those who are hypersensitive, or allergic, a single sting can cause serious swelling of the throat and paralysis of the respiratory system, possibly leading to death. Some people actually get stung by bees or injected with bee venom on purpose as part of apitherapy.
photo: Wausberg
photo: Wausberg
Six minutes after the stinger is removed:
photo: Wausberg
One day later:
photo: SuperManu
Why would someone WANT to be stung? How is bee venom collected for medical use?
Apitherapy has been practiced for centuries and uses the products of bees for health benefits. Apitherapy includes the use of honey, pollen, propolis, royal jelly, and venom from honeybees. Honeybee venom is used in apitherapy to help alleviate medical conditions such as arthritis and multiple sclerosis. Bee venom is even used for people with severe bee allergies in very small doses to help them build immunity to bee stings. These healing effects have been noted for many years and now studies are being done that prove the efficacy of bee venom treatments.
Could you imagine a doctor’s office with a hive of bees, ready to use for treatments? Quite a funny picture, isn’t it? Doctor’s who practice apitherapy actually use preparations from collected bee venom. Beekeepers who collect venom for medical reasons have developed methods of collection that kill as few bees as possible. A sheet of glass and a wire grid that gives a mild electric shock is used. When the honeybee lands and gets a little shock, she stings the glass. Her stinger does not get stuck and so she will survive. The venom dries on the glass and is scraped off. The dried venom is a white to yellowish powder that can be specially prepared back into a liquid used to inject patients. Balms and ointments are also made, but do not have the same strength as an injection.
Is bee venom the same as wasp venom?
Theses two different stinging insects have similar ingredients in their venom. The major difference is the percentage of the amounts of the different substances varies between the species. Wasps have more enzymes that break down cell material. Bees have far more melittin that stimulates anti-inflammatory response. There is one chemical that bees, wasps, and ants share with plants. It is called formic acid and many plants use it for defense. It is what causes plants, like nettle, to sting when touched or poked.
Did you do any of your own research this week? What did you discover about bee venom? Use the comments and share your knowledge!
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